Heart failure is a progressive syndrome that begins with a chronic condition that often leads to Acute Decompensated Heart Failure, an unstable condition requiring immediate medical treatment.
Hospitalization due to ADHF marks a critical stage in the progression of chronic heart failure resulting in an acute event, requiring hospitalization.
However, post-discharge mortality reaches 10% within 3 months and 20% within 6 months. Rehospitalization for an acute event reaches a rate of 20% with 3 months and 30% within 6 months.
At the present time, no treatment has been shown to improve patient outcomes (post-discharge mortality and rehospitalization).
In our Phase 2 clinical trial, ViCardia intends to show that GP531 improves patient outcomes post-discharge. If successful, GP531 would provide the clear pathway to a life-saving therapy for millions of patients worldwide.
As such, ViCardia intends to show that GP531 improves the lifespan of the ADHF patient and reduces the overall financial burden to the health system.
Role of Mitochondria in Sustaining Life
Overall Health and Longevity
Mitochondria
are no longer considered to be solely the static powerhouses of the cell.
Essential to Sustaining Life
and meeting the energy requirements of the cell through oxidative phosphorylation. They are now regarded as highly dynamic organelles with multiple functions, playing key roles in cell survival and death.
Mitochondrial Dysfunction
is associated with various disease conditions including acute decompensated heart failure, neurological disorders such as Parkinson’s and metabolic disorders such as diabetes.
Aging
Mitochondria are also associated with the general aging process of individual cells with further consequences to overall health and longevity.
The Normal Human Heart
a finely tuned, exquisitely balanced, endurance athlete powered by the Mitochondria.
1
Each day, the human heart beats about 100,000 times and pumps approximately 10 tons of blood through the body.
2
The heart cycles about 13.4 lbs between Adenosine Tri-Phosphate (ATP) and Adenosine Di-Phosphate (ADP) every day - 20 to 30 times the heart’s own weight.
3
Adequate amounts of ATP must be generated to support the heart’s contractile demands and maintain viability for the other main organs.
